PeptiGrowth Inc.

<span>PG-002</span>TGFβ1 Inhibitor (TGFβ1 Binding Peptide)

PG-002TGFβ1 Inhibitor (TGFβ1 Binding Peptide)

Small molecule inhibitors “kinase inhibitors” have problems on its specificity and its necessity to act in cells, and in addition, neutralizing antibodies are costly and also difficult to prove animal-free.
Our PG-002 is a special peptide that binds TGFβ1 ligand outside the cell and exerts inhibitory activity.
Since it is produced by complete chemical synthesis, we are able to provide animal-free certification.

Method for Inhibiting TGFβ1 Signal

Method for Inhibiting TGFβ1 Signal 1
Method for Inhibiting TGFβ1 Signal 2
Method for Inhibiting TGFβ1 Signal 3

*This is for illustrative purpose.

Equivalent Inhibitory Activity to TGFβ-Neutralizing Antibody

The inhibitory activity against TGFβ1 was measured by SBE Reporter Assay, and PG-002 showed 100% inhibitory activity at 10nM against 0.13nM TGFβ1 (right figure). Using the panel assay, we also confirmed that it does not inhibit other signaling pathways.

Equivalent Inhibitory Activity to Neutralizing Antibodies

PG-002 Product Overview

Formulation Lyophilized
Storage Condition ≦-20℃
Purity ≧95% (HPLC)
Molecular Weight 2587.90 (Acetate)
Product Size 10µg, 100µg per a glass vial

Sample Requests and Purchases of Our Products

For inquiries regarding growth factor-substituting peptides, please contact the CONTACT Inquiry Form or the following sales agents. In addition to testing and research purpose, we are also able to provide GMP-compliant products that can be supplied in bulk shipments, and used to manufacture regenerative medicine and cell therapy.