PeptiGrowth Inc.

<span>PG-003</span>BDNF Alternative Peptide (TrkB Agonist)

PG-003BDNF Alternative Peptide (TrkB Agonist)

Fully-Chemically Synthesized Peptide with Activity Equivalent to BDNF

Like growth factor BDNF, PG-003 is a growth factor alternative peptide with agonistic activity against the TrkB receptor. In the field of regenerative medicine and cell therapy for the nervous system, which has been extensively researched and developed in recent years, BDNF Alternative Peptide can be used in maintaining the survival and inducing differentiation of nervous system cells.

Induces Dimerization of TrkB and Exerts Biological Activity similar to BDNF

TrkBのダイマー化 イメージ1
TrkBのダイマー化 イメージ2
TrkBのダイマー化 イメージ3

*This is for illustrative purpose.

We performed a functional comparison test between our BDNF Alternative Peptide (PG-003) and commercially available recombinant BDNF.
From the results, PG-003 showed the property which promotes the phosphorylation of TrkB receptor and the expression of NFAT-responsive reporter gene at the same level per molecule compared with recombinant BDNF.
The molecular weight of TrkB agonist peptide is approximately 5.1 kDa, which is approximately 2.5 times smaller than that of recombinant BDNF.

TrkB phosophorylation
Reporter gene activation

Applications Data

We asked Jiksak Bioengineering Inc. to evaluate the behavior of neurite bundle elongation using their proprietary technology, Nerve OrganoidTM, with BDNF or PG-003. As a result, when PG-003 was used, thicker and longer neurite bundles were formed.


PG-003 Product Overview

Formulation Lyophilized
Storage Condition ≦-20℃
Purity ≧95% (HPLC)
Molecular Weight 5151.66 (Acetate)
Product Size
(Quantity equivalent to recombinant BDNF)
10µg per a glass vial
(Equivalent to recombinant BDNF Approx. 25µg)

Information sheet

Sample Requests and Purchases of Our Products

For U.S. customers, the smallest volumes of PG-001~PG-006 are currently available on For inquiries regarding bulk orders of PG-001~PG-006, please contact us directly through the inquiry form on our website.
For customers in the European region, Stratech and Tebubio offer a complete lineup of all products.