PG-003BDNF Alternative Peptide (TrkB Agonist)

Fully-Chemically Synthesized Peptide with Activity Equivalent to BDNF

Like growth factor BDNF, PG-003 is a growth factor alternative peptide with agonistic activity against the TrkB receptor. In the field of regenerative medicine and cell therapy for the nervous system, which has been extensively researched and developed in recent years, BDNF Alternative Peptide can be used in maintaining the survival and inducing differentiation of nervous system cells.

Induces Dimerization of TrkB and Exerts Biological Activity similar to BDNF

*This is for illustrative purpose.

We conducted a functional comparison test between our BDNF Alternative Peptide (PG-003) and commercially available recombinant BDNF. From the results, PG-003 exhibited properties that promote the phosphorylation of the TrkB receptor and the expression of the NFAT-responsive reporter gene at levels equivalent to recombinant BDNF on a per-molecule basis. The molecular weight of PG-003 is approximately 5.1 kDa, which is approximately 2.5 times smaller than that of recombinant BDNF. Therefore, on a mass concentration basis (ng/mL), PG-003 demonstrates comparable activity at 2.5 times less concentration than recombinant BDNF.

Applications Data

We asked Jiksak Bioengineering Inc. to evaluate the behavior of neurite bundle elongation using their proprietary technology, Nerve OrganoidTM, with BDNF or PG-003. As a result, when PG-003 was used, thicker and longer neurite bundles were formed.

Reference

Teng Hu, et al., (2024). Myokine BDNF highly expressed in Type I fibers inhibits the differentiation of myotubes into Type II fibers. Molecular Biology Reports 51:1143.

Stability Data ＆ Safety Data

Stability Data in Serum Free Medium at 37℃
Residual Property data

PG-003 Product Overview

Formulation	Lyophilized
Storage Condition	≦-20℃
Purity	≧95% (HPLC)
Molecular Weight	5151.66 (Acetate)
Product Size	10 µg (equivalent to rBDNF 25 µg) 100 µg (equivalent to rBDNF 250 µg) 1 mg (equivalent to rBDNF 2.5 mg)

Information sheet

Sample Requests and Purchases of Our Products

We offer our products worldwide through the following distributors. Please contact the relevant distributors depending on your region. Please note that currently, we offer all products except PG-009 through distributors. For inquiries regarding PG-009 and bulk orders, please contact us directly through the inquiry form on our website.

Additionally, we provide 1 free sample per product to each organization/lab for our products currently on the market. Please fill out the Sample Request Form to request free samples.

Distributor

Scientist.com	https://app.scientist.com/inventory?q=&filters%5Bmanufacturer_name%5D%5B%5D=PeptiGrowth&filters%5Binventory_config_uuid%5D%5B%5D=b2c86b9f-e0eb-48b3-b138-66161a43f02c
Stratech	https://www.stratech.co.uk/
Genesee Scientific	https://geneseesci.com/
Abacus dx	https://www.abacusdx.com/
Labscoop	https://labscoop.com/us/en
Thomas Scientific	https://www.thomassci.com/browse-by/suppliers/peptigrowth