PeptiGrowth Inc.

<span>PG-010</span>TPO Alternative Peptide (TPOR agonist)

PG-010TPO Alternative Peptide (TPOR agonist)

Fully-Chemically Synthesized Peptide with Activity
Equivalent to TPO

PG-010 is composed of a cyclic peptide that binds to the thrombopoietin receptor (TPOR) and functions as a growth factor substitute peptide, demonstrating agonistic activity towards TPOR.

Induces Dimerization of TPOR and Exerts Biological Activity similar to TPO

TPO Alternative Peptide (TPOR agonist)

*This is for illustrative purpose.

Recombinant TPO and PG-010 activities were compared using ERK phosphorylation and reporter gene activation under JAK2-STAT5 signaling pathway. The results indicated that PG-010 demonstrated activity nearly equivalent to TPO on a molar basis, showing similar activity at 2.6 times less concentrations than recombinant TPO based on mass concentration (ng/mL).

ERK phosphorylation
Reporter gene activation

PG-010 Product Overview

Formulation Lyophilized
Storage Condition ≦-20℃
Purity ≧95% (HPLC)
Molecular Weight 7148.02 (acetate)
Product Size 10 µg per a glass vial (*equivalent to rTPO 26 µg)
25 µg per a glass vial (*equivalent to rTPO 65 µg)

Information sheet

Sample Requests and Purchases of Our Products

We offer our products worldwide through the following distributors. Please contact the relevant distributors depending on your region. Please note that currently, we offer all products except PG-009 through distributors. For inquiries regarding PG-009 and bulk orders, please contact us directly through the inquiry form on our website.

Additionally, we provide 1 free sample per product to each organization/lab for our products currently on the market.  Please fill out the Sample Request Form to request free samples.