PeptiGrowth succeeded in developing a peptide that has the same receptor activation ability and cell proliferation promotion ability as HGF. PG-001, an alternative peptide to HGF, induces dimerization of c-Met receptors and exerts biological activity, similar to activities of HGF.
*This is for illustrative purpose.
We conducted a functional comparison test between our HGF Alternative Peptide (PG-001) and commercially available recombinant HGF. From the results, PG-001 demonstrated properties that promote the phosphorylation of the c-Met receptor and the proliferation of HUVEC at the same level per molecule compared to recombinant HGF. Considering that the molecular weight of PG-001 is approximately 4.7 kDa, which is about 16 times smaller than that of recombinant HGF, on a mass concentration basis (ng/mL), PG-001 exhibits comparable activity at 1/16th of the concentration of recombinant HGF.
Professor Hideki Taniguchi at the Institute of Medical Science, University of Tokyo conducted proliferation and cloning tests of liver cells derived from induced pluripotent stem cells (iPS cells) using recombinant HGF or PG-001. As a result, it was confirmed that PG-001 has activity equivalent to HGF at the same level.
Stability Data in Serum Free Medium at 37℃
Residual Property data
| Formulation | Lyophilized |
|---|---|
| Storage Condition | ≦-20℃ |
| Purity | ≧95% (HPLC) |
| Molecular Weight | 4825.39 (Acetate) |
| Product Size | 5 µg (equivalent to rHGF 80 µg) 50 µg (equivalent to rHGF 800 µg) 500 µg (equivalent to rHGF 8 mg) |
We offer our products worldwide through the following distributors. Please contact the relevant distributors depending on your region. Please note that currently, we offer all products except PG-009 through distributors. For inquiries regarding PG-009 and bulk orders, please contact us directly through the inquiry form on our website.
Additionally, we provide 1 free sample per product to each organization/lab for our products currently on the market. Please fill out the Sample Request Form to request free samples.
PeptiGrowth Inc.
Nihonbashi Life Science Building 7, 9-10, Nihonbashi Horidomecho 1-chome, Chuo-ku, Tokyo 103-0012, Japan
TEL +81-70-7789-3905