PeptiGrowth Inc.

<span>PG-013</span>IL-15 Alternative Peptide

PG-013IL-15 Alternative Peptide

Fully-Chemically Synthesized Peptide
with Activity Equivalent to IL-15

PG-013 is a heterodimeric peptide that binds to IL-2Rβ and γc, inducing the dimerization of IL-2Rβ and γc and exhibiting IL-15–like activity.

PG-013 exhibits binding affinity for IL-2β/γc and agonist activity.

IL-15
PG-013 IL-15 Alternative Peptide

*This is for illustrative purpose.

PG-013 showed IL-15–equivalent activation of the JAK/STAT5 reporter and promoted the proliferation of KHYG-1 (human NK cell line).

Reporter assay
Proliferation of KHYG-1 cells

Evaluation of NKT cell proliferation and activity

Frozen immature NKT cells were thawed and cultured for 10 days in medium containing either IL-15 or PG-013 to induce proliferation and maturation. The mature NKT cells were then evaluated for cell proliferation, and cytotoxicity activity against K562 cells. PG-013 induced robust cell proliferation (>12-fold increase), and yielded PG-013-matured NKT cells exhibited cytotoxic activity equivalent to or even exceeding that of IL-15-matured NKT cells.

NKT Cell Count
Cytotoxicity Activity of NKT Cell

Sample Requests and Purchases of Our Products

We offer our products worldwide through the following distributors. Please contact the relevant distributors depending on your region. Please note that currently, we offer all products except PG-009 through distributors. For inquiries regarding PG-009 and bulk orders, please contact us directly through the inquiry form on our website.

Additionally, we provide 1 free sample per product to each organization/lab for our products currently on the market.  Please fill out the Sample Request Form to request free samples.

Distributor

Scientist.com https://app.scientist.com/inventory?q=&filters%5Bmanufacturer_name%5D%5B%5D=PeptiGrowth&filters%5Binventory_config_uuid%5D%5B%5D=b2c86b9f-e0eb-48b3-b138-66161a43f02c
Stratech https://www.stratech.co.uk/
Genesee Scientific https://geneseesci.com/
Abacus dx https://www.abacusdx.com/
Labscoop https://labscoop.com/us/en
Thomas Scientific https://www.thomassci.com/browse-by/suppliers/peptigrowth